Morbus Meulengracht Forum
GERMAN / DEUTSCHES Morbus Meulengracht Forum => Heilmittel => Symptomlinderung und Hilfreiches => Sulphoraphan: Brokkomax - Brokkolisprossen etc. => Thema gestartet von: Medizinmann99 am 17. Dezember 2006, 20:55:05
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Der Beni Adams von www.gilbertssyndrome.com
Diese D-Glucarategeschichte ist mir neu. Ist wohl sinnvoll das im Hinterkopf zu behalten :-book
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It's a good email. Here is the information I've collected on broccoli:
http://www.lef.org/protocols/prtcl-143a.shtml
A phytoextract, D-glucarate, has been shown to support the glucuronidation pathway by inhibiting the activity of beta-glucuronidase. D-glucarate may be obtained naturally by emphasizing apples, grapefruit, broccoli, and brussels sprouts in the diet and by supplementing with calcium-D-glucarate and vegetable concentrates. According to data released from the University of Texas M.D. Anderson Cancer Center, D-glucarate inhibited beta-glucuronidase by 57% in the blood, 44% in the liver, 39% in the intestines, and 37% in the lungs, thus protecting the action of the glucuronidation pathway (Dwivedi et al. 1990).
http://www.arrowheadhealthworks.com/TMG.htm
"Liver Disorders: As a part of liver-healing and protection formulas. Increases SAM levels in the liver, enables the liver to metabolize fat and protect against many challenges such as alcohol induced cirrhosis. TMG will also decrease BILIRUBIN, alkaline phosphotase, and several other liver enzymes related to a large variety of liver disorders. Significant liver benefits have been shown in 20 studies. Dose range: 500-1,500 mg. daily."
www.wizardofeyez.com/tmg.html
"Trimethylglycine (TMG) is an excellent source of methyl groups and is found in good quantities in broccoli and beets."
http://jn.nutrition.org/cgi/content/abstract/135/5/1051
Cruciferae Interact with the UGT1A1*28 Polymorphism to Determine Serum Bilirubin Levels in Humans1,2
Studies indicate that foods from the botanical families Cruciferae (e.g., broccoli), Rutaceae (citrus), Liliaceae (e.g., onions), and Leguminosae (legumes) may increase UGT activity.
For total, direct, and indirect bilirubin measures, there was no significant association with any botanical group independently. There was a significant inverse association between all 3 bilirubin measures and interaction of UGT1A1*28 genotype with Cruciferae intake (P < 0.02 for each measure); individuals with the 7/7 genotype had reduced bilirubin concentrations with increased intake of cruciferous vegetables, whereas individuals with the 6/6 or 6/7 genotype did not. With regard to UGT1A1-conjugated carcinogens (e.g., heterocyclic amines, polycyclic aromatic hydrocarbons), individuals with decreased UGT1A1 activity due to the 7/7 genotype may be at greater risk for carcinogenesis, but our results imply that they also may have greater opportunity to decrease that risk through dietary intervention.
In Short: UGT1A1 substrates: carcinogens such as heterocyclic amines and polycyclic aromatic hydrocarbon (although it might be refering to those carcinogens processed by UGT1A1 such as PhIP). Cruiferous vegetables (e.g. broccoli) help those with Gilbert's Syndrome by increasing activity of UGT1A1
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=72.topic
hayesmoore
This is very likely to be because broccoli contains a chemical called sulphoraphane. This is a powerful Uridine Diphosphate Glucoronosyltranferase (the deficient enzyme in GS) inducer. This chemical is found in many fruits and veg including red grapes.
However, Sulphoraphane is roughly 50 yes fifty times more concentrated in sprouts-not brussel sprouts but sprout of young premature frtuits and veg. It is most highly concentrated in Broccoli sprouts.
there is much research going on into broccoli sprouts (mainly john hopkins uni) and this chemical as a possible cancer preventative as the UDPGT enzyme is an important one in breaking down carcinogenic chemicals
That last part mentions research at John Hopkins University, which might be a good place to look for more information.
Benji
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